IN VIVO SCIENTIFIC TESTS
Some scientific studies showing the efficacy of MYCO-AD® in the control of the most important
mycotoxins affecting commercial birds are shown below.
Evaluation of Myco-Ad® efficacy in reducing the toxicity caused by feeding synthetic ochratoxin and aflatoxin in commercial broilers
Facilities: International Animal Research
Institution, Querétaro, Mexico.
Type of Birds: Broilers.
MYCO-AD inclusion rate: 2.5 kg per metric
ton of feed.
Synthetic mycotoxin concentration
in the feed: Aflatoxin = 7500 ppb plus
Ochratoxin = 2000 ppb. High levels were
used in order to show the damage caused by these mycotoxins. Under field
conditions, lower levels of natural
mycotoxins can cause damage more
readily.
Reference: A. Casarin, M. Forat, E. Soto,
M. Contreras and D. Zaviezo.
Evaluation of the efficacy of a commercial
HSCAS to reduce toxicity of T 2 toxin in
broiler chicks. 2005 International Poultry
Scientific Forum. Atlanta, GA, USA.
Table 1. Effect of MYCO-AD on daily feed intake (DFI), average daily gain (ADG), feed
conversion rate (FCR) and initial/final body weight of aflatoxin-fed, 24-day-old broilers.
| TREATMENT |
DFI
g |
ADG
g |
FCR |
BW
4 days
g |
BW
24 days
g |
| Control |
45.90 a |
28.03 a |
1.637 a |
78.87 a |
639.47 a |
| MYCO-AD |
47.82 a |
27.83 a |
1.717 a |
78.35 a |
634.95 a |
Aflatoxin
(7.5 ppm) |
35.42 b |
18.49 b |
1.915 b |
76.71 a |
446.51 b |
| MYCO-AD + Aflatoxin (7.5 ppm) |
43.01 c |
26.48 a |
1.623 a |
78.90 a |
608.50 a |
a, b, c Values within one column with different letters are significantly different (P< 0.05).
Table 2. Effect of MYCO-AD on liver size and lesions, and mortality rate of aflatoxin fed
24-day-old broilers.
| TREATMENT |
Liver weight/
100g BW |
Liver
gross lesions |
Mort ality
(% ) |
| Control |
3.54 a |
Negative |
0 |
| MYCO-AD |
3.18 a |
Negative |
0 |
Aflatoxin
(7.5 ppm) |
6.14 b |
100% Severe |
8. 3 |
| MYCO-AD + Aflatoxin (7.5 ppm) |
3.83 a |
25% negative
40% mild
25% moderate
10% severe |
0 |
a, b, c Values within one column with different letters are significantly different (P< 0.05).
Table 3. Effect of MYCO-AD on daily feed intake (DFI), average daily gain (ADG), feed
conversion rate (FCR), and initial and final body weight (BW) of ochratoxin-fed 28-day-old
broilers.
| TREATMENT |
DFI
g |
ADG
g |
FCR |
7 days
BW
g |
28 days
BW
g |
| Control |
53.87 a |
31.05 a |
1.734 a |
82.45 a |
734.50 a |
| MYCO-AD |
54.85 a |
31.12 a |
1.762 a |
85.36 a |
738.80 a |
| Ochratoxin (2.0 ppm) |
52.91 a |
29.67 b |
1.783 a |
82.63 a |
705.70 a |
MYCO-AD + Ochratoxin
(2.0 ppm) |
53.89 a |
32.63 a |
1.651 b |
85.19 a |
770.04 a |
a, b, c Values within one column with different letters are significantly different (P< 0.05).
Table 4. MYCO-AD effect on liver and kidney size, as well as lesions in ochratoxin fed
28-day-old broilers.
| TREATMENT |
Liver weight/
100g BW |
Liver
gross lesions |
kidney
weight/
100g BW |
kidney
gross lesions |
| Control |
4.90 |
Negative |
1.09 a |
Negative |
| MYCO-AD |
4.96 |
Negative |
1.19 a |
Negative |
Ochratoxin
(2.0 ppm) |
4.89 |
19% mild
63% moderate
18% severe |
1.37 b |
88% severe
6% mild
6% moderate |
MYCO-AD +
Ochratoxin
(2.0 ppm) |
4.81 |
44% negative
19% mild
31% moderate
6% severe |
1.33 b |
62% negative
19% mild
6% moderate
13% severe |
a, b, c Values within one column with different letters are significantly different (P< 0.05).
Conclusions
Effect on aflatoxin and ochratoxin
® MYCO-AD controlled the deleterious effects
caused by both mycotoxins, showing a
statistically significant difference in favor of
® MYCO-AD + mycotoxin fed group when
compared with the group that received only
mycotoxins.
Nutrient absorption
No negative effects were seen on
productive parameters of birds treated only
with MYCO AD®. Results were statistically
similar to those of the controls.
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