IN VITRO EVALUATION

In vitro evaluation is the first step that must be taken for the identification of a mycotoxin binder. This is so important that many researchers consider that if the product does not work in vitro, it will hardly work when used in animals (in vivo).

Generally, it is considered that a product with 80% absorption capacity in vitro can potentially do a good job in vivo.

It is important that in vitro results represent the net adsorption of the product, eaning that both the adsorption and desorption process has occurred, through a pH change, mimicking what occurs in the gastrointestinal tract of animals.
Adsorption results from tests performed only at a low pH do not assure that the product can retain the mycotoxin when the pH rises.

Graph 2. Mean and maximum net adsorption capacity of MYCO-AD in the high performance liquid chromatography (HPLC) test using 5 ppm (5000 ppb) of all 7 mycotoxins tested, with a MYCO-AD® level of 2.5 kg/metric ton (commercially-recommended dose).





Technical information about Myco-Ad

• Introduction
• In vivo scientific tests
  • Evaluation of Myco-Ad® efficacy in reducing the toxicity caused by feeding synthetic ochratoxin and aflatoxin in commercial broilers
  • Evaluation of Myco-Ad efficacy in decreasing the toxicity of t-2 toxin in commercial broilers
  • Evaluation of the efficacy of Myco-Ad to decrease the toxicity caused by natural mycotoxin contamination in commercial layers
• In vitro evaluation
• History of Mycotoxins Absorbants / Clay Chemistry Applied to Nutrition.
• Clays. Physicochemical characteristics
• Question and Answer Session
• Lesions caused by mycotoxins in chickens
• Return to Myco-Ad